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Introduction: The covid-19 pandemic has left a high number of infected and dead in the world, where several social measures have been imposed on the population, especially social isolation. Objective: Given this scenario, based on Vygotsky's socio-historical theory, this original article aimed to identify the meanings of social isolation in the covid-19 pandemic for Brazilian youth. Method: A survey was carried out, with the participation of 571 young Brazilians, women and men aged between 18 and 25, who answered a sociodemographic questionnaire and the Free Word Association Method (FWAM), analyzed with the help of IRaMuTeQ. Results: The results showed that virtualized socialization is insufficient for the social demand of young people, as evidenced by the most evoked words in category 1, "Homesickness” (χ² = 55,41);"Boredom” (χ² = 50,06);"Anxiety” (χ² = 42,67);"Loneliness” (χ² = 37,15);"Sadness” (χ² = 32,78). It was also identified that their routine was transformed with the insertion of obligations and leisure primarily in the home environment, demonstrated by the prevalence of words like "House” (χ² = 116,18);"Home Office” (χ² = 26,06);"Movie” (χ² = 26,06);"Mask” (χ² = 24,96);"Alcohol” (χ² = 21,67);"Lockdown” (χ² = 21,67), in category 2. Still, young people brought their resignifications in this period, in the face of collective responsibility, indicated by the choice of words in category 3, such as "Care” (χ² = 84,05);"Responsibility” (χ² = 59,21);"Respect” (χ² = 55,03);"Prevention” (χ² = 52,68);"Empathy” (χ² = 34,06);"Protection” (χ² = 21,99). Conclusions: It is concluded that isolation brought negative consequences on relationships and mental health of young people, but also a greater social awareness. © 2023, Universidad Simon Bolivar. All rights reserved.
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Background: The four-drug combo has becoming one of the main induction treatment for TE NDMM patients (pts). We conducted a phase 2 study to assess the safety and preliminary efficacy of Cyclophosphamide (C), thalidomide (T), dexamethasone (d)-(CTd) and Dara combination. MAXDARA study has shown in the primary analysis with 21 included patients (pts), 4 and 8 pts MRD negativity after four induction cycles and two consolidation cycles post transplant, respectively. (Crusoe E et al ASH 2020, 2416 poster presentation). In the present analysis we evaluate the effect of deep response rate on PFS. Method(s): This is a phase II, open-label single-center clinical trial. The main inclusion criteria were: TE NDMM, creatinine clearance > 30 ml/min, normal cardiac, renal and liver function and the ECOG performance status = 0 - 2. The protocol was Dara-CTd for up to four 28-day induction cycles: C-500mg oral (PO) on days 1,8 and 15, T at 100-200mg PO on days 1 to 28, (d) at 40mg PO on days 1,8,15 and 22 and Dara at 16mg/Kg/dose intravenous (IV) on days 1,8,15 and 22 during cycles 1 - 2 and every other week in cycles 3 - 4, followed by ASCT. All pts received up to four 28-day consolidation cycles that was started at D+30 after ASCT: Dara at 16mg/Kg and (d) at 40mg every other week, associated with T at 100mg PO on days 1 - 28. Dara at 16mg/Kg was used monthly as maintenance until progression or limiting toxicity. The MRD was evaluated by next-generation flow (NGF) 10-6 and PET-CT was performed when the patient obtained NGF negativity or finished consolidation. PFS outcome was estimated using Kaplan-Meier method and PFS analysis were performed based on the different response rates. (Data cut-off was April 2022) Results: A total of 24 pts were included. The median age being 58 (range 37- 67 years), 15 (62.5%) pts were female, 22 (92%) were non-white, 6 (25%) had an R-ISS = 1, 12 (50%) had an R-ISS = 2 and 4 (16%), an R-ISS = 3. Sixteen (66.7%) pts were IgG isotype and Six (25%) had high-risk chromosomal abnormalities [1q+, del17p, t(4;14) or t(14;16)]. To date, 23 pts have completed induction, 21 performed transplant and 14 are still in treatment after one year of dara maintenance. By ITT analysis, 22 pts (91.6%) achieved (> PR) after 4 induction cycles. One pts achieved SD, one MR and one sCR. Eleven (39%) pts achieved PR, and 10 (35.7%) VGPR. After two consolidation cycles, ORR was 68%, 8 (28.6%) and 11 (39.3%) pts obtained sCR and VGPR, respectively. The best response during any time of the treatment were PR in 3 (12.5%) pts, VGPR in 12 pts (50%) and sCR in 8 (33.3%) pts. In a ITT analysis, NGF MRD 10-6 negativity were observed in 4(16.6%) after four induction cycles, and in 17 (70.8%) pts after two consolidation cycles post-ASCT. In a ITT analysis, after a median follow up (FU) of 26 months, the PFS was 37months for the entire group. The median PFS comparing sCR vs < VGPR were 37m vs 27m (p = 0.021), respectively, and comparing MRD negative by NGF vs no, had impacted even more on PFS with a median of 37m vs 16m (p = 0.004), respectively. The OS was not yet achieved and 83% of the patients still alive after a median FU of 27m. Four pts died from infection, two of them related with covid infection (one before transplant and one during maintenance). Another case post-transplant, considered not related to the investigational agent and one after consolidation, related to the investigational agent. Summary/Conclusion: The Daratumumab - CTd protocol is an active and safe regimen capable of producing deep and sustainable responses. The deeper response rate impacted on PFS, confirm that MRD negativity is critical to patient outcome. Copyright © 2022
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While the lockdown significantly reduced face-to-face meetings, video conferencing platforms began to be used widely to leverage different sectors, such as academia. In this scope, scientific events such as seminars and conferences were migrating to the online environment. However, online events usually do not dedicate time to group activities, decreasing the chances of building academic and professional partnerships and decreasing social interactions and networking opportunities that naturally occur in face-to-face events. This paper aims to present a series of dynamics carried out using Zoom and Mentimeter platforms within the scope of the “ehSemi” Conference to create interaction between people and encourage potential scientific networking, which happens in face-to-face conferences and is significantly lost online. Furthermore, the paper discusses the role of timing, and moderators, among other essential factors that boost the social components in the online environment. Despite, given the current pandemic situation, studying the new role of videoconferencing and interactions therein appears timely and interesting, limitations and ideas for future work are presented to improve results and provide details that were not covered in this work. © 2022 15th International Conference on ICT, Society and Human Beings, ICT 2022, 19th International Conference on Web Based Communities and Social Media, WBC 2022 and 14th International Conference on e-Health, EH 2022 - Held at the 16th Multi Conference on Computer Science and Information Systems, MCCSIS 2022. All rights reserved.
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This article addresses the perceptions of university students about the Portuguese National Health Service (NHS) on Instagram (IG), which is the main profile of the country's government on the platform. Young people are the largest audience of this social media (SM), which has been considered as a tool to promote public health. Therefore, this study aims at identifying how young adults perceive the content available in @sns_pt regarding health and well-being topics. The qualitative methodology was used, and a survey was carried out with undergraduate students from the University of Aveiro. It was applied digitally in June 2020, 90 days after the World Health Organization (WHO) announced the new coronavirus pandemic. The survey presents 15 questions, divided into three axes: consumption of SM, use of IG, and posts evaluation. A total of 39 valid questionnaires were obtained. The sample is made up of students between the ages of 19 and 45 years old, being 61.5% female and 38.4% male. The results obtained show that @sns_pt is known by 43.5% of the respondents and 12.8% follow the account. Also, 10.2% reported having accessed the profile for the first time after the pandemic started. The posts focused on images attracted the attention of students, as well as the contents regarding the users' routines. © 2021 AISTI.
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When designing a digital solution aimed at community initiatives, it is necessary to have a great concern with all potential users, ensuring it can be easily used by anyone, regardless of any sensory or motor limitations. This article reports the developmental stage of a mobile application, which aims to promote collaboration and cooperation between different agents involved in the territorial innovation process. Accessibility and microcopy evaluations of the application prototype were carried out to improve its accessibility and ensure its use by users in several circumstances, contexts, and conditions. Due to the Covid-19 pandemic current restrictions, the tests were performed remotely, allowing the development team to deepen knowledge about the different methods and tools for implementing remote tests. This paper presents the results of this methodology of evaluation, which contributed to assess the CeNTER mobile application's adequacy and make improvements aimed at ensuring its accessibility and universality. © 2021 AISTI.
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Vaccine candidates against COVID-19 have diverse compositions, from traditional inactivated virus vaccines to various new-generation vaccines. Currently, approximately 175 research teams worldwide are studying various vaccine possibilities as the necessity to vaccinate the entire population against the SARS-CoV-2 virus is urgent. Although, the development of a safe and effective COVID-19 vaccine is not easy, the manufacturing, distribution, and administration of the vaccine can also face extraordinary challenges. In this review, we enhance some of the current knowledge regarding the clinical trial phases on different COVID-19 vaccine candidates, its potential strengths and disadvantages, and to discuss ethical aspects and their chances of success in large-scale applications.